Category Archives: Pharma

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VIX Crashes Back Below 20 After Futures Expiration


Spot VIX briefly spiked above 25 when hotflation sent markets into brief turmoil, but once the Feb VIX futures had expired, it was a one-way-street of VIX-selling euphoria…

 

 

Story image for vix from CNBC

Former CFTC commissioner: Whistleblower allegation about …

CNBC-4 hours ago
The allegation by a whistleblower, in a letter to the Securities and Exchange Commission, of potential manipulation of the VIX, a key gauge of market fear and volatility, "rings true," a former market regulator told CNBC on Wednesday. Formally called the CBOE Volatility Index, probes possible manipulation of volatility index

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Wall Street climbs as traders follow closely the potential inflation reading

The stock exchange rises as shareholders watch closely the future inflation reports

 The stock market climbed on Tuesday,buoyed by Amazon.com and Apple, while investors focused on upcoming inflation data that could upset the market’s fragile recovery.

 
Amazon.com (AMZN.O) rose 1.9 percent while Apple (AAPL.O) added 0.73 percent, both helping the S&P 500 shake off a negative open to the session and climb 0.13 percent in afternoon trade.

Evidence of the impact of unstable, at times frenetic markets was obvious everywhere in recent days. Traders who commonly pick up their phones to exchange tidbits of data requested to speak after the close. Capital markets bankers cut meetings short to run back to their desks.
Among the biggest movers was sportswear retailer Under Armour (UAA.N), up more than 17 percent on strong quarterly sales, and AmerisourceBergen (ABC.N), up 8 percent after the Wall Street Journal reported Walgreens (WBA.O) was attempting to buy out the drug distributor.

Cleveland Fed president Loretta Mester, a voting member in the central bank’s rate-setting committee this year, mentioned the current stock market sell-off and jump in unpredictability will not spoil the economy’s over-all strong opportunities.

After a very volatile week that pushed the market into correction territory, U.S. stocks increased approximately 3 percent over Friday and Monday, their greatest two-day gain since June 2016.

 

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Goldman Sachs CEO is trailing Bitcoin

 Know that folks also were vacillatingwhen paper money displaced gold,"  Goldman Sachs CEO, Blankfein remarked on Tuesday

His indication follows a WSJ report that the investment bank was researching a new investment operation dedicated to bitcoin and other cryptocurrencies in response to client demand

The plan was in early stages and may not proceed, the  report noted, citing sources familiar with the matter.

Blankfein’ observation is in sharp contrast to comments made by JPMorgan’s CEO,  Jamie Dimon, who named bitcoin a "fraud".

Speaking at a bank investor conference in New York last month, Dimon said, "The currency isn’t going to work. You can’t have a business where people can invent a currency out of thin air and think that people who are buying it are really smart."

It is worse than tulips bulbs," Dimon declared, referring to a famous market bubble from the 1600s.

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Forex News: US Dollar June 15 2017 (15)

United States Dollar(USD) To Canadian Dollar(CAD) Exchange Rates Today

As of Thu Jun 15, 2017 10:04 PM EDT Data is provided by eSignal, a division of Interactive Data Corp. To encourage thoughtful and respectful conversations, first and last names will appear with each submission to CBC/Radio-Canada’s online communities (except in children and youth-oriented communities). Pseudonyms will no longer be permitted.

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US dollar news for 15/05/2017

The U.S. dollar is the world’s most heavily traded and most widely held currency. In fact, the United States is the largest national economy in the world, with a gross domestic product (GDP) of nearly $14 trillion. When economic activity in the United States is strong, the dollar strengthens and the EUR/USD exchange rate adjusts accordingly. When economic activity slows down, the dollar weakens. Because the United States is also considered a safe haven for assets of all kinds, the dollar tends to rise during times of political or global financial tumult.Related link:

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A number of athletes are acing bans for using meldonium.

Meldonium –

Metabolic modulators are classified as S4 substances according to the WADA banned substances list. WADA classes the drug as a metabolic modulator, just as it does insulin. On April 13, 2016, it was reported that WADA had issued updated guidelines allowing less than 1 microgram per milliliter of Mildronate for tests done before March 1, 2016.

The chemical name of meldonium is 3-(2,2,2-trimethylhydraziniumyl) propionate. It is a structural analog of γ-butyrobetaine, with an amino group replacing the C-4 methylene of γ-butyrobetaine. γ-Butyrobetaine is a precursor in the biosynthesis of carnitine. Since January 1, 2016, Mildronate has been on the World Anti-Doping Agency’s list of banned drugs. Although initial reports suggested meldonium is a non-competitive and non-hydroxylatable analogue of gamma-butyrobetaine; further studies have identified that Mildronate is a substrate for gamma-butyrobetaine dioxygenase. X-ray crystallographic and in vitro biochemical studies suggest that meldonium binds to the substrate pocket of γ-butyrobetaine hydroxylase and acts as an alternative substrate, and therefore a competitive inhibitor. These substances have the ability to modify how some hormones accelerate or slow down different enzymatic reactions in the body. In this way, these modulators can block the body’s conversion of testosterone into estrogen, which is necessary for females. Based on the overall effects these drugs have, they have been banned since 2001 from men’s competitions and 2005 for women’s. Normally, this enzyme’s action on its substrates γ-butyrobetaine and 2-oxoglutarate gives, in the presence of the further substrate oxygen, the products L-carnitine, succinate, and carbon dioxide; in the presence of this alternate substrate, the reaction yields malonic acid semialdehyde, formaldehyde (akin to the action of histone demethylases), dimethylamine, and (1-methylimidazolidin-4-yl)acetic acid, “an unexpected product with an additional carbon-carbon bond resulting from N-demethylation coupled to oxidative rearrangement, likely via an unusual radical mechanism.” The unusual mechanism is thought likely to involve Steven’s type rearrangement. The agency cited that “preliminary tests showed that it could take weeks or months for the drug to leave the body”. Mildronate is widely used by athletes to increase athletic performance and endurance.

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Reference

“Meldonium (Mildronate): What Is It And What Does It Do?” Medical …. n.p., 21 Apr. 2017.Web. 1 May. 2017.

“Meldonium 500/250mg (Mildronate) Tablets Review.”. n.p., 1 May. 2017.Web. 1 May. 2017.

“Meldonium” Wikipedia. n.p., 21 Apr. 2017.Web. 1 May. 2017.